Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin.
Identifieur interne : 002283 ( Main/Exploration ); précédent : 002282; suivant : 002284Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin.
Auteurs : E. Hamsíková ; H. Závadová ; M. Zaoral ; J. Jezek ; K. Bláha ; V. VonkaSource :
- The Journal of general virology [ 0022-1317 ] ; 1987.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Hemagglutinins, Viral, Peptides.
- chemical : Antigen-Antibody Complex, Hemagglutinin Glycoproteins, Influenza Virus, Macromolecular Substances.
- immunology : Influenza A virus.
- Influenza A Virus, H3N2 Subtype, Radioimmunoassay.
Abstract
Rabbits were immunized with a synthetic octadecapeptide corresponding to the sequence ser-91 to leu-108 of the haemagglutinin heavy chain of H3N2 influenza A viruses. They developed antibodies reactive in solid-phase radioimmunoassay (SPRIA) with the peptide and with haemagglutinins of various H3N2 viruses but not of heterotypic H1N1 and H2N2 viruses. The antibodies were also non-reactive in the haemagglutination-inhibition or neutralization test. Influenza H3N2 virus replicated in the lungs of mice immunized with the peptide to the same extent as in the control mice. Of 27 human sera possessing anti-H3N2 activity or seven sera from rabbits immunized with either virions or haemagglutinins of various influenza A viruses, none was reactive with the peptide in SPRIA.
DOI: 10.1099/0022-1317-68-8-2249
PubMed: 3612090
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000484
- to stream PubMed, to step Curation: 000484
- to stream PubMed, to step Checkpoint: 000430
- to stream Ncbi, to step Merge: 001078
- to stream Ncbi, to step Curation: 001078
- to stream Ncbi, to step Checkpoint: 001078
- to stream Main, to step Merge: 002392
- to stream Main, to step Curation: 002283
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin.</title><author><name sortKey="Hamsikova, E" sort="Hamsikova, E" uniqKey="Hamsikova E" first="E" last="Hamsíková">E. Hamsíková</name></author><author><name sortKey="Zavadova, H" sort="Zavadova, H" uniqKey="Zavadova H" first="H" last="Závadová">H. Závadová</name></author><author><name sortKey="Zaoral, M" sort="Zaoral, M" uniqKey="Zaoral M" first="M" last="Zaoral">M. Zaoral</name></author><author><name sortKey="Jezek, J" sort="Jezek, J" uniqKey="Jezek J" first="J" last="Jezek">J. Jezek</name></author><author><name sortKey="Blaha, K" sort="Blaha, K" uniqKey="Blaha K" first="K" last="Bláha">K. Bláha</name></author><author><name sortKey="Vonka, V" sort="Vonka, V" uniqKey="Vonka V" first="V" last="Vonka">V. Vonka</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1987">1987</date><idno type="RBID">pubmed:3612090</idno><idno type="pmid">3612090</idno><idno type="doi">10.1099/0022-1317-68-8-2249</idno><idno type="wicri:Area/PubMed/Corpus">000484</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000484</idno><idno type="wicri:Area/PubMed/Curation">000484</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000484</idno><idno type="wicri:Area/PubMed/Checkpoint">000430</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000430</idno><idno type="wicri:Area/Ncbi/Merge">001078</idno><idno type="wicri:Area/Ncbi/Curation">001078</idno><idno type="wicri:Area/Ncbi/Checkpoint">001078</idno><idno type="wicri:doubleKey">0022-1317:1987:Hamsikova E:immunogenicity:of:a</idno><idno type="wicri:Area/Main/Merge">002392</idno><idno type="wicri:Area/Main/Curation">002283</idno><idno type="wicri:Area/Main/Exploration">002283</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin.</title><author><name sortKey="Hamsikova, E" sort="Hamsikova, E" uniqKey="Hamsikova E" first="E" last="Hamsíková">E. Hamsíková</name></author><author><name sortKey="Zavadova, H" sort="Zavadova, H" uniqKey="Zavadova H" first="H" last="Závadová">H. Závadová</name></author><author><name sortKey="Zaoral, M" sort="Zaoral, M" uniqKey="Zaoral M" first="M" last="Zaoral">M. Zaoral</name></author><author><name sortKey="Jezek, J" sort="Jezek, J" uniqKey="Jezek J" first="J" last="Jezek">J. Jezek</name></author><author><name sortKey="Blaha, K" sort="Blaha, K" uniqKey="Blaha K" first="K" last="Bláha">K. Bláha</name></author><author><name sortKey="Vonka, V" sort="Vonka, V" uniqKey="Vonka V" first="V" last="Vonka">V. Vonka</name></author></analytic><series><title level="j">The Journal of general virology</title><idno type="ISSN">0022-1317</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen-Antibody Complex</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Hemagglutinins, Viral (immunology)</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (immunology)</term><term>Macromolecular Substances</term><term>Peptides (immunology)</term><term>Radioimmunoassay</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Complexe antigène-anticorps</term><term>Dosage radioimmunologique</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Hémagglutinines virales (immunologie)</term><term>Peptides (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Structures macromoléculaires</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antigen-Antibody Complex</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Macromolecular Substances</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hémagglutinines virales</term><term>Peptides</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Radioimmunoassay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Complexe antigène-anticorps</term><term>Dosage radioimmunologique</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Structures macromoléculaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rabbits were immunized with a synthetic octadecapeptide corresponding to the sequence ser-91 to leu-108 of the haemagglutinin heavy chain of H3N2 influenza A viruses. They developed antibodies reactive in solid-phase radioimmunoassay (SPRIA) with the peptide and with haemagglutinins of various H3N2 viruses but not of heterotypic H1N1 and H2N2 viruses. The antibodies were also non-reactive in the haemagglutination-inhibition or neutralization test. Influenza H3N2 virus replicated in the lungs of mice immunized with the peptide to the same extent as in the control mice. Of 27 human sera possessing anti-H3N2 activity or seven sera from rabbits immunized with either virions or haemagglutinins of various influenza A viruses, none was reactive with the peptide in SPRIA.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Blaha, K" sort="Blaha, K" uniqKey="Blaha K" first="K" last="Bláha">K. Bláha</name><name sortKey="Hamsikova, E" sort="Hamsikova, E" uniqKey="Hamsikova E" first="E" last="Hamsíková">E. Hamsíková</name><name sortKey="Jezek, J" sort="Jezek, J" uniqKey="Jezek J" first="J" last="Jezek">J. Jezek</name><name sortKey="Vonka, V" sort="Vonka, V" uniqKey="Vonka V" first="V" last="Vonka">V. Vonka</name><name sortKey="Zaoral, M" sort="Zaoral, M" uniqKey="Zaoral M" first="M" last="Zaoral">M. Zaoral</name><name sortKey="Zavadova, H" sort="Zavadova, H" uniqKey="Zavadova H" first="H" last="Závadová">H. Závadová</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002283 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002283 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:3612090
|texte= Immunogenicity of a synthetic peptide corresponding to a portion of the heavy chain of H3N2 influenza virus haemagglutinin.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:3612090" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |